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A small percentage of users report sleep disturbances with evening dosing, possibly related to nitric oxide system effects

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doi: 10.1016/j.biomaterials.2008.12.053
For example, if you are using oral nicotine replacement therapy (nicotine gum or lozenges), it may help to use a different type instead such as patches or nasal spray

Some patients need Vitamin B12 injections every two or three months for the rest of their life
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