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10.1016/j.bbcan.2020.188427 79 KimM.-C.BorcherdingN.AhmedK

More observational studies are needed to further understand the role of IGF1 in the development of specific SPCs, as well as to determine which pathways downstream of the IGF1R are involved in this process

Obesity is a predominantly pro-inflammatory process, and the main mechanism is that in obesity, classically activated macrophages (M1) have higher concentrations than alternatively activated macrophages (M2), expressing pro-inflammatory cytokines, and activating pro-inflammatory pathways, such as the JNK and TNF-kB signaling pathways, which lead to low-grade chronic inflammation throughout the body (190)
doi: 10.1016/j.nut.2021.111169

Liu Y, Tian S, Ning B et al (2022) Stress and cancer: the mechanisms of immune dysregulation and management

Although we failed to detect 5-HT in Mir-NCM, previous report showed that mirtazapine promoted 5-HT release from serotonergic neurons and indirectly stimulates 5-HT1A receptors by blocking 5-HT2 and 5-HT3 receptors 16
