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This process leads to the production of anti-inflammatory cytokines such as IL-10, PGE 2 , and TGF- by phagocytes ( One notable strategy used by the parasite consists of the expression of phosphatidylserine (PS) on its surface ( LBs from macrophages are sites for PGE 2 synthesis by COX-2, and as previously mentioned, PGE 2 together with TGF- may favor a Th2-polarization benefiting parasite replication ( Finally, thromboxane A2 (TBXA 2 ) may also influence macrophage function

In addition, muscle NMN levels were significantly elevated in Ab68-treated mice, indicating potent systemic inhibition of CD38-mediated catabolism of NAD + precursors 15

This enables the development of personalized dosing regimens or adjunctive microecological interventions (e.g., probiotic/prebiotic supplementation) to enhance therapeutic efficacy while reducing the incidence of drug resistance and adverse effects