l-carnitine fat loss mechanism Role of in the transport of long-chain fatty acids through Carnitine Metabolism and Its Role

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Nutrients per daily dose (= 2 capsules) NRV* coenzyme Q10 100 mg ** L-carnitine tartrate 600 mg (= 408 mg L-carnitine) ** niacin (vitamin B3) 16 mg 100% *% NRV (reference values - EU 1169/2011) **none

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

Int J Mol Sci 17(7):1006 Ko M-H, Yang M-L, Youn S-C, Lan C-T, Tseng T-J (2016) Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury