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For instance, butyrate can improve paracellular permeability by modulating hypoxia-inducible factor-1 and epithelial tight junction CLDN1 [133]

Saaranen, M

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Interventions currently under investigation include stabilizing CL, preventing its oxidative damage, enhancing its biosynthesis and remodelling, and promoting targeted mitochondrial repair (Table 1)

Nat Commun 10(1):5151 Chang X, Zhu W, Zhang H, Lian S (2017) Sensitization of melanoma cells to temozolomide by overexpression of microRNA 203 through direct targeting of glutaminase-mediated glutamine metabolism

Defined as elevated plasma levels of homocysteine, a non-protein forming amino acid, HHcy has been identified as a risk factor for cardiovascular disease, stroke, VCID, and AD (Vermeer et al., 2002