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Estimation and Validation of an Effective Ergothioneine Dose for Improved Sleep Quality Using Physiologically Based Pharmacokinetic Model

In a similar model, rectal supplementation with L-serine induces modifications in bacterial community structure, characterized by an increase of OTUs (Operational Taxonomic Unit), the phylum Bacillota, the orders Clostridiales and Lactobacillales, and a reduction in the phylum Bacteroidota 145

Its importance is supported by the existence of a molecular machinery that makes it particularly effective

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Servais A, Saitovitch A, Hummel A, Boisgontier J, Scemla A, Sberro-Soussan R, Snanoudj R, Lemaitre H, Legendre C, Pontoizeau C, Antignac C, Anglicheau D, Funalot B, Boddaert N (2020) Central nervous system complications in adult cystinosis patients

Multidrug resistance-associated protein 2 (MRP2) is an efflux transporter of EGCG and its metabolites in the human small intestine