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Conversely, integrase strand transfer inhibitors (INSTIs) such as Dolutegravir and Raltegravir are generally considered to have the most favorable mitochondrial safety profile, with little evidence of direct mtDNA toxicity

For instance, food-based dietary guidelines could be updated to include specific, mechanism-aware advice, such as recommending one serving of cruciferous vegetables three to four times per week to leverage Nrf2 activation, or promoting the inclusion of fermented foods like yogurt or kimchi to support gut health via microbial metabolites

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Gut dysbiosis-derived B-glucuronidase promotes the development of endometriosis