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Firstly, our study further strengthen the evidence of well-designed RCTs of ALC in HE and introduce the view and methodology of evidence-based medicine (EBM) when compared with a previous review included 3 clinical trials reported in 2008.28 Secondly, perhaps more and more investigators from different countries will be interested and highlight the role of ALC and conduct studies with far more important findings, so as to provide another choice drug for HE

AOD9604 vs Tesamorelin: The comparison of tesamorelin vs AOD9604 is particularly relevant, since both peptides are used for fat-loss research but work through different mechanisms

Data availability Data is provided within the manuscript or supplementary information files

Elevated intracellular glutamine was also implicated in ferroptosis induction via glutaminolysis yet the chemical processes that lead to increased cellular oxidative stress await to be dissected 13

Sun C et al

doi: 10.1111/J.1365-3040.2005.01487.X 111 LianJ.ChengL.WangX.ChenY.DengC.WangY.et al