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The case for a better shuttle isnt three separate arguments

Our results show that the labelling percentage in lactate M + 3 (Fig

Sun K, Li X, Scherer PE

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Gonzalez-Rodriguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillon J, Lo IO, Corazzari M, Fimia GM, Piacentini M, Muntane J, Bosca L, Garcia-Monzon C, Martin-Sanz P, Valverde AM (2014) Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

Thus, denitrification in the Archean anoxic atmosphere, associated with NO bioavailability, may have been the basis for a long-term evolutive trend regarding NO biosource and signaling