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There was some increase in urinary excretion of essential minerals, especially potassium and chromium

doi: 10.1038/nature25973

Vascular dark circles result from thin periorbital skin (thinnest on body at 0.5mm vs 2mm average facial skin) allowing visualization of underlying blood vessels and pooled deoxygenated blood appearing blue-purple through skin surface

Lushchak VI (2012) Glutathione homeostasis and functions: potential targets for medical interventions

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In some cases, increased vitamin C can result in kidney stones or even hemodialysis in people who are G6PD-deficient (a disease in which some drugs cause red blood cells to break down)