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In these situations, patients may have high B12 on blood work but still exhibit neurological symptoms of deficiency (tingling, numbness, cognitive changes)

An analytical methodology called CellSearch has been approved by the US FDA to enumerate CTCs in breast, colon, and prostate cancer patients (Janssen Diagnostics 2014)

DNA testing required for formal diagnosis (not a first-line investigation, exclude other causes first) Pre-pregnancy carrier testing of partner is important Rare causes of microcytic anaemia Chronic inflammation Lead poisoning (high blood lead level) Sideroblastic anaemia Normocytic normochromic anaemia Haemolytic anaemia Acute haemolysis in childhood can be a life-threatening illness and all cases should be discussed with a haematologist Admit children with haemolytic anaemia for observation

Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells