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In a smaller, double-blind, placebo-controlled trial in 256 older adults, ages 60-75 years, co-supplementation with 300 mg/day of all - rac --tocopherol and 400 mg/day of vitamin C for one year reduced a biomarker of oxidative stress (malondialdehyde) but had no effect on cognitive performance measured by the Mini Mental State Examination (MMSE) scoring system (109)

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This state of oxidative and nitrosative stress is a hallmark of numerous neurodegenerative diseases, underscoring the central role of astrocytic redox regulation in maintaining CNS homeostasis and preventing neuropathology