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10.1111/bph.13517 20 DashS.AydinY.WidmerK

Cureoglu S, Baylan MY, Paparella MM

however, it is believed this interaction is not entirely due to CYP450 enzyme induction

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doi: 10.1097/MOL.0b013e3283508fed

Overall, the benefits of aerobic exercise are limited by the functional reserve beyond the mutation load in MM patients, and the magnitude of improvement is largely determined by the underlying genotype ( MM patients experience exercise intolerance and delayed post-exercise recovery as a result of defective oxidative phosphorylation, which limits ATP production ( MM patients typically exhibit elevated oxidative stress due to ETC defects, resulting in excessive ROS production that damages mtDNA