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DIA files were processed using Spectronaut with default settings, with PTM localization activated and site confidence score cutoff set to 0 (for peptide-level analysis of dilution benchmark), 0.75 (for spectral library analysis) or 0.99 (for direct DIA analysis), data filtering set to Q- value and Normalization Strategy set to Local Normalization

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In the first, issued in March 2021, the FDA indicated that travel restrictions due to the COVID-19 pandemic prevented a timely inspection of the companys European contract manufacturing site

Distribution of angiotensin II type-2 receptor (AT2) mRNA expression in the adult rat brain

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Autophagy is a phagocytic degradation process whose deregulation may contribute to neuronal cell death and is involved in the mechanisms of pathologic conditions, such as cerebral ischemia (Galluzzi et al., 2016