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levels between 200400 pg/mL may signal functional insufficiency despite normal lab ranges

doi: 10.3390/nano13152185 216 Gutirrez-lzateKBeltrn-CottaLAdos Santos RekowskyBSCavalheiroCPPereira da CostaM

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Zheng Y, Zhang J, Zhao Y, Zhang Y, Zhang X, Guan J, Liu Y, Fu J (2021) Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis

This condition, combined with continued exposure to stressors and vulnerability, may predispose it to alter the immune system with the simultaneous release of pro-inflammatory cytokines, which in turn may activate the production of reactive oxidative species and, together, may eventually reach the brain and promote a neuro-inflammatory state [127,128]