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Practical Takeaways There is some limited evidence supporting AOD 9604s impact on lipid metabolism, suggesting its potential to induce weight loss, specifically in animal models

Preclinical studies show no significant toxicity at therapeutic doses, with treated animals displaying no adverse behavioral changes or organ dysfunction

Hormonal deficiencies and mineral imbalances are common as well

Notably, NNMT inhibition did not impact food intake in the DIO mice nor produce any overt signs of toxicity or adverse behavioral effects at the pharmacologically effective dose

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Finally, the relative abundance of sequences that could not be assigned to a defined genus was significantly higher in vehicle- and 5A-1MQ-treated mice switched from WD to LD relative to the WD control group (the former before FDR correction only