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Description
It is twice as common in women than in men, hence, it was relabeled early on as stiff-person syndrome instead of the original stiff-man syndrome. Patients typically present with muscle spasms and stiffness, concurrently in the thoracolumbar paraspinal and abdominal muscles, resulting in difficulties turning and bending (28

Increased level of exogenous zinc induces cytotoxicity and up-regulates the expression of the ZnT-1 zinc transporter gene in pancreatic cancer cells
Targeting the high-expression enzymes in cancer amino acid metabolism via small molecule inhibitors or RNAi-targeting approaches is emerging as a crucial therapy (Martinez-Outschoorn et al., 2017

Padilla F, Brenner J, Prada F, Klibanov AL
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maintenance treatments or lifestyle changes are needed to sustain results
