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slowed gastric emptying (gastroparesis) GLP-1 agonists stimulate GLP-1 receptors in the CNS including vagal efferent fibers in the brainstem

However, accurate quantification and standardization of protein biomarkers are major technical challenges, and the relationship between protein expression and disease progression across different cardiovascular disease subtypes requires further investigation

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doi: 10.1186/S12894-025-01728-4 45

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Remarkably, the charge distribution and shape of TrxR1 in this site is different with respect to TGR 33 due to the presence of charged and bulky residues, i.e., E337, D338, E341, E368 and K389 in human TrxR1 in place of A436, G437, Q440, S467 and D488 in TGR