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Patients who should NOT use it include those with uncontrolled diabetes, active malignancy or personal history of hormone-sensitive cancer, or pituitary disease

Abstract The purpose of this study was to investigate the utility of plasma pharmacokinetic and pharmacodynamic measures including plasma deoxynucleosides, homocysteine and methylmalonic acid concentrations in understanding the time course and extent of the inhibition of thymidylate synthase (TS) by pemetrexed in the context of a phase I/II combination study with vinorelbine

Of course, the same idea can be applied in much higher dimension

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These effects make it a promising candidate for future studies on complex wound healing scenarios

Subscript T and R represent the test preparation and the reference preparation for extravascular administration, respectively, while D represents the administered dose