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CHB is also characterized by T-cell exhaustion, which is worsened by alcohol and includes up-regulation of PD-1, CTLA-4, and TIM-3 (66), impaired mitochondrial function in T cells (23, 67), and impaired antigen-presenting function of dendritic and Kupffer cells (6870)

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Owing to its high lipid content, particularly its enrichment in polyunsaturated fatty acids (PUFAs), the brain is especially vulnerable to ferroptosis (13)

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The pharmacological use of ellagic acid-rich pomegranate fruit