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Autoimmune conditions including Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy attack nerve myelin directly

4F, G, SP effectively facilitated the degradation of the KEAP1 protein, yet this process could be impeded by MG132, demonstrating that the degradation of KEAP1 is dependent on the proteasome-mediated pathway

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Ding F, Ma B, Nazary-Vannani A, et al

Studies have shown that A1AR activation upregulates the protective factor IL-11 through activation of ERK and hypoxia-inducible factor 1-, as well as induces cytoprotective heat shock protein 27 (HSP27) synthesis through p38 MAPK activation phosphorylation, thereby reducing renal tubular apoptosis and inflammation [51]

Dexmedetomidine ameliorated cognitive impairment generated by intestinal ischemia reperfusion in mice with possible link to the anti-inflammatory action through the locus coeruleus norepinephrine system