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Figure1

A wide gap between an effective dose and the highest dose tested does not straightforwardly translate into a wide human margin of safety, because interspecies scaling of peptides is not a simple body-weight multiplication

Nikolaus S, Mller HW, Hautzel H

Sci Rep 5, 13553 (2015)

In circadian biology, DUBs serve as key modulators of clock protein stability, ensuring the robustness and proper timing of transcriptional-translational feedback loops that drive 24-h rhythms (Harris-Gauthier et al., 2022)

Protein purification Cell pellets were resuspended in ice-cold lysis buffer containing 20 mM Tris-Cl (pH 8.0), 150 mM NaCl, 0.2 mM PMSF, 20 g/mL DNase I, and 20 M DNQX
