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ITC analysis of a PL-containing synthetic peptide from DENND4C established direct binding to recombinant VPS29 with an affinity ( K d ) of 15.4 M, that was blocked by mutation of the PL motif or by the addition of a competing VPS29-binding macrocyclic peptide RT-D1 (Fig
It had advanced into clinical trials as an anti-atherosclerotic agent, although it failed in a phase III trial (Muldrew and Franks, 2009)
& Aliasgharzadeh, A
The methylcitrate cycle remains fully functional in M
10.1016/j.redox.2021.102122 179 RuiuR.RolihV.BolliE.BarutelloG.RiccardoF.QuaglinoE.et al (2019)
