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Although contradictory results support that hypomethylation of SNCA intron 1 does not interfere with the transcription of the SNCA gene [248], a subsequent study using advanced technical approaches confirmed that the particular methylation is cell-type specific and indeed it regulates SNCA expression [249]

Hypoxia-inducible factor 1 (HIF1) serves as a critical metabolic sensor in Th17 cells, and GLS1 is essential for Th17 differentiation and glycolysis promotion

Wittig, I

Metabolic profiling by Seahorse assay suggested that melatonin treated ILC2s exhibited decreased rates of basal respiration ( Figure 5P ), decreased spare respiratory capacity ( Figure 5Q ), and both reduced active rates of glycolysis ( Figure 5R ) as well as reduced glycolytic capacity ( Figure 5S )

The broader message is simple: more is not always better

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