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The primary concern raised by the Norwegian IRB was that this RCT was violating the principle of clinical equipoise

DMSO is used to dissolve test compounds in in vitro drug discovery [18] [19] and drug design [20] screening programs, including high-throughput screening programs

However, -galactosidase is only present in lysosomes, whereas -glucuronidase is expressed in lysosomes and the microenvironment of solid tumors

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It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton

Roland, C