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These drugs exert significant cochleotoxic effects through multiple biochemical pathways

acnes can stimulate adaptive immune responses by inducing the secretion of pro-inflammatory cytokines (Moreno-Arrones and Boixeda, 2016), such as IFN- and IL-17A, from Th1 and Th17 lymphocytes through Toll-like receptors (TLRs) (Ozlu et al., 2016), activation of inflammasomes (Moreno-Arrones and Boixeda, 2016), induction of matrix metalloproteinases (MMPs) (Hammam et al., 2020), and stimulation of antimicrobial peptide (AMP) activity (Harder et al., 2013)

The methoxy functional group (OCH 3 ) refers to a methyl group (CH 3 ) covalently bonded to an oxygen atom (O)

British thoracic society guideline for non-CF bronchiectasis

Recent studies suggest that noninvasive plantar stimulation may enhance peripheral sensory processing and reduce FOG episodes

Patients may also experience fatigue, weakness, dizziness, irritability, headaches, hunger, and difficulty maintaining energy when calorie intake is too restricted