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VD The main cause of VD is chronic cerebral hypoperfusion (CCH) caused by chronic cerebral blood flow (CBF) and a variety of vascular pathologies

Interestingly, changes in calcium homeostasis in the brain may contribute to the cognitive decline associated with normal aging and possibly to the development of neurodegenerative disorders (61, 62)

Morphine-mediated release of astrocyte-derived extracellular vesicle miR-23a induces loss of pericyte coverage at the blood-brain barrier: Implications for neuroinflammation

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albicans switches its metabolic mode, mainly relying on glycolysis in the hypoxic mucosal environment and oxidative phosphorylation in the oxygen-rich environment, adapting to different microenvironments of the host and consuming glucose to weaken the function of macrophages (Pellon et al., 2022)

Reduced Binding Protein Affinity: In the body, most IGF-1 is bound to a family of proteins known as IGF-binding proteins (IGFBPs)