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As a BCL-2 inhibitor, Navitoclax neutralizes the drug resistance of senogenic BRAF inhibitor, vemurafenib [138]

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Without formal reproductive toxicity studies following OECD Test Guideline 414 (prenatal developmental toxicity) and 416 (two-generation reproduction toxicity), we are operating without the data that regulatory science requires before concluding a compound is safe for use during conception attempts or pregnancy

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