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Both oxidative stress and viral infection (e.g., HHV-6) are believed to be responsible for mitochondrial fragmentation in ME/CFS [120,121]

( a ) Representative flow cytometry plot showing proportions of donor (CD45.2) and recipient (CD45.1) derived haematopoietic cells in spleens of chimeric mice generated using the CRISPR-Cas9 based approach

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doi: 10.3389/fphar.2025.1587314 Received 04 March 2025 Accepted 21 April 2025 Published 28 April 2025 Volume 16 - 2025 Edited by Ramzi Mothana, King Saud University, Saudi Arabia Reviewed by Jovana Rajkovic, University of Belgrade, Serbia Sidharth Mehan, Indo-Soviet Friendship College of Pharmacy, India Updates Copyright 2025 Jiang, Lhamo, Ma, Ye, Chen, He, Xu and Huang