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Urine is, indeed, important in elimination of lead released from the bones or body compartments, i.e., in chelation therapy where upon quenching of lead from different sites of the body it is expelled through urine (Flora et al., 2012)

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The organization of complex I is such that a portion of the complex is embedded in the inner mitochondrial membrane and the rest of the complex protrudes into the mitochondrial matrix

Front Behav Neurosci

Kohjin K.K

These data illustrate how the enzymatic action of GPx-1 links it to the intracellular GSH/GSSG redox couple transferring redox stress in the cell to the easily restored GSSG rather than reactive protein thiols (189, 196)