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Reverse electron transport (RET) drives electrons from complex II to I via CoQ, reducing NAD + to NADH and increasing NADH/NAD + ratios (Kowalczyk et al., 2021)

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As a monotherapy, it significantly outperformed placebos, and when used as an adjunctive therapy alongside prescription antidepressants, it showed highly robust efficacy, leading to higher response and remission rates than using antidepressants alone

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The test involved placing the mice in a cylindrical glass tank with a diameter of 10 cm and a height of 25 cm