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Therefore, impairment of the insulin signaling pathway (PI3K/Akt/mTOR pathway) leads to IR, which may induce the synthesis and deposition of advanced glycation end products (AGEs), ROS, and reactive nitrogen species

Inhibition of HIF-1 activity has a significant inhibitory effect on primary tumor proliferation and metastasis to lymph nodes and lungs in mice by orthotopic transplantation of TNBC (251, 252)

About this article Cite this article Mittal, R., Gupta, N

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doi: 10.1016/j.indcrop.2019.05.032 68 SaeedMNaveedMBiBiJKambohAAArainMAShahQAet al

Efferocytosis The process for phagocytosing dead or dying cells that is initiated by the recognition of phosphatidylserine lipids on the cell surface (lipids normally present on the internal side of the plasma membrane)