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doi: 10.1186/s12958-015-0032-1 290 KurkowskaWBogaczAJaniszewskaMGabryETiszlerMBellantiFet al

NatureMDPI Long term human safety, pharmacokinetics, optimal dose, systemic exposure and oncologic risk signals are undefined (absence of evidence, not evidence of safety)

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Previously, Palacino et al

54 In addition, increased Nox activity has been observed in different animal models of hypertension including ATII infusion, 14, 55, 56 deoxycorticosterone acetate (DOCA)-salt hypertension, 57 renovascular hypertension 58 and in spontaneously hypertensive rats