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Among promising drug candidates, the small molecule 3,4diisobutyryl derivative of auxarthrol Aisolated from endophytic fungi of Euphorbiaceae plants and chemically modifieddirectly targets the LIC1 protein

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The relative tumor volume curve indicated that the ZFPG and ZFP + US groups had a smaller tumor volume compared to the Control, US, and ZFP groups

however, continuous muscle injury triggers a chronic inflammatory response, which can aggravate the underlying lesions by degrading intact proteins, implying reduced performance and compromised health [52, 72, 73]

Lipid A is responsible for the toxicity of LPS and contains two phosphate groups coupled to glucosamines, allowing LPS to bind TLR4, triggering an inflammatory response (e.g., the release of pro-inflammatory cytokines) (Figure 1) [16]
