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doi: 10.3389/fncir.2021.711564 [DOI] [PMC free article] [PubMed] [Google Scholar] 53.Menon P, Kiernan MC, Vucic S

Many individuals with AUD also experience other psychiatric conditions, such as anxiety disorders, post-traumatic stress disorder (PTSD), or bipolar disorder

This extreme reactivity is due to its small size and lack of charge, allowing rapid diffusion across cellular structures

The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron

Proinflammatory cytokines such as Tumor Necrosis Factor (TNF)-, interleukin (IL)-1 or IL-18 induce the endocytosis of epithelial apical junctional proteins [120], promoting an increment in intestinal permeability [121]

For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability