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As shown in Figure 3, by the use of these kits the values of GSSG (and of the ratio GSH/GSSG) resulted to be significantly different from those obtained by the reference method (sample pre-treatment with NEM) in some comparative experiments with several rat tissues and cultured cells (our laboratory, unpublished data)

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Demonstrating the importance that oxidative stress may play in ME/CFS, the study was able, for the first time, the authors said, to directly link increased levels of oxidative stress with reduced mitochondrial functioning in both ME/CFS and long-COVID patients

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Drugs like phenytoin, carbamazepine, primidone, valproic acid, and others can increase oxidative degradation of vitamin K

Mediators Inflamm 2016:9523628