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It is intricately associated with metabolic dysfunctions linked to obesity and demonstrates a bidirectional connection with various comorbidities (271, 272)

These findings hint that the optimal pairing of TLR agonists with ICB may enhance the potency of human anticancer vaccines

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He L., Feng D., Guo H., et al

Then, ATP depletion leads to the failure of energy-dependent ion pumps (e.g., Na + /K + -ATPase), resulting in ionic imbalances, including the influx of calcium (Ca 2+ ), sodium (Na + ), and chloride (Cl ) ions into the cell, and the efflux of potassium (K + ) [23]

Clinical trials of ultra-high-dose methylcobalamin in ALS