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CACT acetylation mechanism is in line with a dynamic post-translational protein control that could undergo an on/off switch induced by deacetylation/acetylation linked to the availability of acetyl-CoA 57
It seems that the reason carnitine was unable to increase muscle carnitine concentration in these studies for 2 reasons: Poor bioavailability (only 20% for of a 2-6 g dose is absorbed) and Because the transport of carnitine into the muscle was limited
four studies, 369 participants)
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doi: 10.1016/j.bcp.2012.12.021
These findings emphasize the need for caution regarding carnitine supplementation, particularly in individuals with preexisting metabolic or cardiovascular vulnerabilities [55]
