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Abdul N

Neurotrauma 31, 346357

Later, in the 1980s, the development of high-pressure liquid chromatography methods allowed for rapid determination of homocysteine concentrations in 1000s of samples, thus paving the way for epidemiological studies that revealed significant associations between relatively small elevations of homocysteine in blood and cardiovascular, cerebrovascular, and peripheral vascular diseases (7, 46)

Novel NAChemin adducts and GSHhemin adducts (1st products) are formed by the nucleophilic addition of thiols both to the ethylene bridges of the tetrapyrrole ring (four sites available) and the double bonds of the side chains of hemin (two sites available)