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Cannabidiol (CBD) use in psychiatric disorders: A systematic review

This transporter maintains the dynamic equilibrium between extracellular cystine and intracellular glutamate by importing cystine while exporting glutamate at a 1:1 ratio ( , depletion of GSH, or inhibition of GPX4 activity can lead to the accumulation of iron-dependent lipid peroxides, ultimately initiating ferroptosis ( 2+ levels in the substantia nigra of PD rats, inhibits neuronal ferroptosis, decreases ROS production, downregulates malondialdehyde (MDA) and -synuclein (-Syn) expression, elevates GSH levels, and ameliorates motor deficits

Addiction Substance abuse encompassing alcohol, cocaine, methamphetamine, and heroin can trigger addiction by disrupting multiple neural pathways and initiating complex neuromodulatory processes that alter behavior

Reduced inflammation was also demonstrated by Bolcas et al

Neuron 50(1):115125