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Importantly, when combined with curcumin, 3,4-DHPV exhibited a strong synergistic anti-inflammatory effect at low micromolar concentrations (5 M 3,4-DHPV + 5 M curcumin), markedly reducing the expression of multiple pro-inflammatory genes (e.g., IL-6, MCP-1, COX-2, IL-1, TNF-, iNOS) and their secreted protein levels (Marcolin et al., 2025)

Several biological processes rely on it to perform optimally, but levels diminish as we age, opening the door to premature cell death, aging, and age-associated diseases and conditions