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Conversely, PDE10A inhibition reduces D 2 receptor activity, which has the potential to alleviate positive symptoms ( 1 and D 2 receptor signaling ( 84 (Zinc41306568) , a dual PDE1B/PDE10A inhibitor, was evaluated for its pharmacological efficacy and safety in a rat model of schizophrenia

Smith-Vikos and Slack, 2012)

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