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Claudio Cavazza, Composition for the Prevention and Treatment of Osteoporosis due to Menopause Syndrome (2002), US Patent 6,335,038, column 4

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In addition, alkylation, acylation, or guanidinylation of the -amino group can finely tune basicity, hydrogen-bond donor/acceptor properties, and lipophilicity, thereby optimizing the efficacy and toxicological profiles of lead compounds

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