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Absorption, systemic exposure, and bioavailability vary greatly depending on the administration route - and these factors determine whether a peptide reaches its target effectively

While early and smaller trials showed promising fat-loss effects, the largest Phase IIb trial did not achieve statistical significance in humans for its primary endpoint of weight reduction, which led to the program being discontinued

Cells were washed three times with RPMI1640 medium and incubated with 1 g ml 1 Alexa Fluor 594 goat anti-rat IgG (HL) for 5 min at 4 C

Realistic expectation: Trial data document the largest weight changes accruing over windows longer than six months

Annals of Clinical Biochemistry, 48(5), 418-432