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(2019) demonstrated that serum levels of TMAO are positively correlated with the serum levels of total BA in patients with MAFLD by conducting a case-control study, and administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in a murine model

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These individuals typically demonstrate cerebrospinal epitheliopathy, blood-CSF barrier (BCB) dysfunction, and elevated cytokine levels [44]

Quantitatively, outliers were screened by examination of studentized residuals whereby values 3 were considered outliers