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When iron-laden transferrin binds to TfR on the cell surface, the resulting complex (TFRC) undergoes clathrin-mediated internalization into endosomes (Figure 3)

[DOI] [PubMed] [Google Scholar] 12.Lemont H, Ammirati KM, Usen N

10.1155/2013/608367 74 MullettS

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There is emerging literature that some of these putative biomarkers may not accurately reflect permeability of the gastrointestinal tract

The risk of predictive DILI is related to the amount of drug-exposure and can be reproducible
