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Description

DHA is generated from MDHA

As a result, these compounds have not progressed to clinical trials as targeted inhibitors

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Indeed, MDA-MB-231 breast cancer cells and non-malignant retinal pigment epithelium cells (hTERT RPE-1) as well as human foreskin fibroblasts (HFF) also showed a significant increase in cell area and FA number upon aldolase depletion but not upon PFK or GAPDH loss, demonstrating that the differential impact of glycolytic enzymes on adhesions is conserved across cell types (Extended Data Fig