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This can trigger downstream pathways leading to apoptosis (programmed cell death), neuronal degeneration, and, ultimately, neurodegenerative diseases like Parkinsons and Alzheimers disease (AD) (Roussel et al., 2013)

[DOI] [PMC free article] [PubMed] [Google Scholar] Kpka A., Ochociska A., Chojnowska S., Borzym-Kluczyk M., Skorupa E., Kna M., Waszkiewicz N

10.1002/humu.21607 Hum

The Role of Lysyl Oxidase in the Pathological Stage of Atherosclerosis: Structural Stabilizer or Disease Driver

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Lastly, when glucose concentrations are low (e.g., during extended fasting), GCK is sequestered in the nucleus by the liver-specific protein, glucokinase regulatory protein (GKRP) (332)