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HA has been demonstrated to have multiple roles in the wound-healing process ( Collagenase Clostridium Histolyticum Collagenase clostridium histolyticum (CCH), previously used in treating Dupuytren contracture, possesses anti-fibrotic properties by degrading the collagen and is the only FDA - approved intralesional drug for treatment of PD ( Although patients with penile curvature from 30 to 90 were included in IMPRESS I/II and the deformity were corrected for mean 17 in CCH-treated group, greater overall satisfaction of IIEF was also achieved in treatment group, indicating that the improvement in satisfaction is associated not only with reduced curvature but also objective elements

Shields CL, Kaliki S, Hutchinson A, Nickerson S, Patel J, Kancherla S, et al

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BAS/1/1624-01-01, FCC/1/1976-20-01, FCC/1/1976-26-01, and Contract No#OSR 4129
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