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In active MS lesions, there is a loss of microglial homeostatic phenotype and acquisition of a reactive one (136)

In the IRI model, elevated expression of the E3 Ub-protein ligase HMG-CoA reductase degradation protein 1 (HRD1) increases ubiquitinated degradation of the -catenin degradation complex, stabilizes -catenin proteins, and thereby enhances Wnt / -catenin signaling[50]

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About 70% of the immune system is localized in the gastro-intestinal tract as GALT (gut-associated lymphoid tissue)

Kopalli SR, Cha K-M, Lee S-H, Hwang S-Y, Lee Y-J, Koppula S, Kim S-K (2019) Cordycepin, an active constituent of nutrient powerhouse and potential medicinal mushroom Cordyceps militaris Linn., ameliorates age-related testicular dysfunction in rats

Die Teilnehmenden haben den gleichen Tagesablauf wie Astronautinnen und Astronauten auf einer Mission: Sie arbeiten als Crew zusammen, haben wissenschaftliche Aufgaben, treiben Sport und mssen sich um ihre Raumstation kmmern